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Updated: Sep 2, 2025

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Multimodal (Non)Linear Optical Nanoimaging and Nanospectroscopy.

Chih-Feng Wang1, Patrick Z El-Khoury1

  • 1Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.

The Journal of Physical Chemistry Letters
|August 3, 2022
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Summary

Recent advances in spectral nanoimaging offer noninvasive characterization of molecular and material systems. This technique provides crucial nanometer spatial and femtosecond temporal resolution for understanding complex interfaces and quantum materials.

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Area of Science:

  • Optics and Photonics
  • Materials Science
  • Spectroscopy

Background:

  • Characterizing molecular and material systems requires noninvasive techniques with high spatial and temporal resolution.
  • Understanding heterogeneous interfaces is key to advancing fields like catalysis, microbial communication, and quantum materials.

Purpose of the Study:

  • To highlight recent advancements in linear and nonlinear spectral nanoimaging.
  • To emphasize the importance of joint nano-femto resolution for characterizing complex systems.
  • To showcase high spatial resolution measurements under ambient conditions.

Main Methods:

  • Linear spectral nanoimaging
  • Nonlinear spectral nanoimaging
  • Optical nanospectroscopy

Main Results:

  • Demonstrations of pioneering work in spectral nanoimaging.
  • Recent advancements enabling noninvasive characterization at the nanoscale.
  • High spatial resolution measurements achieved under ambient laboratory conditions.

Conclusions:

  • Spectral nanoimaging is a powerful tool for noninvasive characterization of molecular and material systems.
  • The joint nano-femto resolution is critical for fundamental understanding of diverse processes.
  • Advancements facilitate the study of complex interfaces and low-dimensional quantum materials.