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Recent advances in macrocyclic arenes-based fluorescent indicator displacement assays.
Qunpeng Duan1, Fei Wang1, Kui Lu1,2
1School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China.
Frontiers in Chemistry
|August 4, 2022
Summary
Macrocyclic arenes are advancing fluorescent indicator displacement assays (F-IDAs) for precise molecular sensing. This review covers progress and future challenges in using these macrocyclic arenes for selective analyte detection.
Area of Science:
- Supramolecular Chemistry
- Analytical Chemistry
Background:
- Macrocyclic arenes, including calixarenes and pillararenes, exhibit unique host-guest binding properties.
- Fluorescent indicator displacement assays (F-IDAs) leverage molecular recognition for sensing applications.
Purpose of the Study:
- To review recent advancements in macrocyclic arene-based F-IDAs.
- To discuss the prospects and challenges in this field of chemosensing.
Main Methods:
- Utilizing macrocyclic arenes (calixarenes, pillararenes) as hosts.
- Integrating various fluorophores for signal transduction.
- Developing F-IDAs for detecting cationic, anionic, and neutral analytes.
Main Results:
- Macrocyclic arene-based F-IDAs demonstrate high specificity and selectivity for diverse analytes.
- Significant progress has been made in designing sophisticated F-IDA systems.
- These assays represent a high level of molecular recognition in host-guest chemistry.
Conclusions:
- Macrocyclic arene-based F-IDAs are a powerful tool for advanced chemosensing.
- Further research is needed to overcome remaining challenges and expand applications.
