Related Experiment Video
Updated: Sep 2, 2025

08:51
Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
Published on: September 4, 2012
19.4K
[Pregnancy-induced post-lipofilling inflammatory mastitis].
G Mambour1, N Wirtzfeld2, Ph Paquet3
1Service de Chirurgie générale, Clinique Saint-Joseph-Vivalia, Arlon, Belgique.
Revue Medicale De Liege
|August 4, 2022
Summary
Autologous fat injections (lipofilling) for breast augmentation can rarely lead to inflammatory mastitis during pregnancy. This case highlights a potential interaction between injected fat and hormonal changes, causing recurrent inflammation.
Area of Science:
- Plastic Surgery
- Obstetrics & Gynecology
- Pathology
Background:
- Autologous fat injection, or lipofilling, is a common procedure for aesthetic and reconstructive breast surgery.
- Complications following lipofilling are infrequent.
- Pregnancy involves significant hormonal changes that can affect breast tissue.
Observation:
- A young female patient experienced recurrent, self-limiting inflammatory mastitis in her breasts after undergoing lipofilling.
- The mastitis episodes occurred during two successive pregnancies.
- The inflammation was localized to the areas previously treated with fat grafting.
Findings:
- This is the first reported case of pregnancy-induced inflammatory mastitis following breast lipofilling.
- The findings suggest a potential interaction between the autologous fat graft and the hormonal milieu of pregnancy.
- This interaction may create a local inflammatory environment in the breast.
Implications:
- The study suggests a novel pathophysiological mechanism for inflammatory mastitis in patients with breast lipofilling.
- Further research is needed to elucidate the exact mechanisms underlying this interaction.
- This case may inform patient counseling and management strategies for women considering or who have undergone breast lipofilling and plan future pregnancies.

