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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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[Young, fit, nonsmoker-That is also typical in lung cancer!]

Sabine Hatzfeld1, Bärbel Söhlke2

  • 1zielGENau e. V., Kerpener Str. 62, 50937, Köln, Deutschland. sabine.hatzfeld@zielgenau.org.

Innere Medizin (Heidelberg, Germany)
|August 4, 2022
PubMed

Insights

Lung cancer affects younger, non-smoking individuals with treatable mutations. Early molecular genetic testing and targeted therapies, facilitated by networks like the national network of genomic medicine (nNGM), improve patient survival and outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Lung cancer presentation extends beyond elderly smokers, including younger non-smokers with actionable mutations.
  • Targeted therapies offer significant survival benefits over traditional treatments for specific patient subsets.
  • Current adoption rates for molecular genetic testing and targeted treatments are increasing but remain suboptimal.

Purpose of the Study:

  • To highlight the need for broader access to molecular diagnostics and targeted therapies in lung cancer.
  • To emphasize the importance of a research-integrated network for ensuring diagnostic and therapeutic quality.
  • To showcase the national network of genomic medicine (nNGM) as a model for collaborative lung cancer care.

Main Methods:

  • Analysis of current trends in molecular genetic testing and targeted treatment uptake in lung cancer.
  • Evaluation of the structure and function of the national network of genomic medicine (nNGM).
  • Assessment of patient engagement and its impact on healthcare system participation.

Main Results:

  • The national network of genomic medicine (nNGM) demonstrates successful cooperation in lung cancer care.
  • The nNGM facilitates patient participation, leading to longer survival and increased patient voice.
  • Well-informed patients are better positioned to benefit from diagnostic and therapeutic advancements.

Conclusions:

  • A structured, research-adjacent network is crucial for equitable access to modern lung cancer diagnostics and treatments.
  • The nNGM model effectively integrates research, diagnostics, and patient advocacy.
  • Empowered and informed patients are key drivers for advancing lung cancer care and outcomes.
Keywords:
Molecular diagnosticsMutationsNational network of genomic medicinePersonalized treatmentTargeted treatment

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