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Updated: Sep 2, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Cancer stem cells in esophageal squamous cell carcinoma
Guorui Sun1, Yanru Yang1, Jin Liu1
1State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi'an, China.
Abstract:
Esophageal squamous cell carcinoma (ESCC) is one of the most intractable challenges among human diseases with poor prognosis and shortness of effective therapeutic options. Cancer stem cells (CSCs), a tumor sub-population, are considered the cause of tumor growth, differentiation, metastasis and therapeutic resistance, etc. In this review, we discuss the known methods for isolation and verification of ESCC CSCs, the biomarkers of ESCC CSCs and their significance in diagnosis and prognosis. Then we review the ESCC CSC signaling pathway and therapeutic resistance. In pace with the detailed studies of ESCC CSCs increasing, treatment strategies of ESCC based on CSCs are becoming more promising.
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