Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Appendix300: Surgical video and patient metadata of 330 laparoscopic appendectomy cases from five institutions.

Scientific data·2026

Same author

Prospective development and validation of an objective classification for difficult facemask ventilation: the MASCAN score.

Anaesthesia·2026

Same author

Pre-operative three-dimensional face scans for predicting difficult facemask ventilation: a prospective development study.

Anaesthesia·2026

Same author

Postoperative hypotension in patients recovering from noncardiac surgery: a prospective, blinded observational study.

British journal of anaesthesia·2026

Same author

Diagnostic value of the percentage of glottic opening score for classifying videolaryngoscopy in children: a prospective validation study.

Anaesthesia·2026

Same author

Intervals for Oscillometric Arterial Pressure Monitoring during Noncardiac Surgery: The "2.5-Minute versus 5-Minute" Randomized Clinical Trial.

Anesthesiology·2026

Search research articles

Related Experiment Video

Updated: Sep 2, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

Predicting liver regeneration following major resection.

Karolin Dehlke¹, Linda Krause², Silvana Tyufekchieva¹

¹Department of General, Visceral and Transplant Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Scientific Reports

|August 4, 2022

Summary

Cytokine and growth factor profiles predict liver regeneration after surgery. Early prediction of post-hepatectomy liver failure (PHLF) and mortality is possible using liquid biopsies, enabling tailored treatments.

More Related Videos

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Related Experiment Videos

Last Updated: Sep 2, 2025

The Influence of Liver Resection on Intrahepatic Tumor Growth

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Area of Science:

Hepatology and Regenerative Medicine
Biomarker Discovery
Surgical Oncology

Background:

Liver failure following liver resection, known as post-hepatectomy liver failure (PHLF), is a severe complication with high mortality.
Individual cytokine and growth factor profiles are potential predictive markers for liver function recovery after surgery.
Understanding these profiles during post-hepatectomy regeneration is crucial for improving patient outcomes.

Purpose of the Study:

To investigate cytokine and growth factor profiles in patients undergoing major liver resection.
To identify predictive signatures for post-hepatectomy liver failure (PHLF), morbidity, and mortality.
To correlate hepatocyte regenerative potential with clinical outcomes.

Main Methods:

Analysis of time-dependent cytokine and growth factor profiles in training (30 patients) and validation (14 patients) cohorts.
Statistical and predictive modeling to identify pathway signatures associated with clinical outcomes.
In vitro proliferation assays using primary human hepatocytes isolated from patient samples.

Main Results:

Common expression trajectories of cytokines and growth factors correlated with PHLF, morbidity, and mortality.
Dynamics of Epidermal Growth Factor (EGF), Hepatocyte Growth Factor (HGF), and Placental Growth Factor (PLGF) were associated with mortality; PLGF also linked to PHLF and complications.
Preoperative cytokine and growth factor signatures predicted mortality, and PHLF prediction achieved AUC > 0.75 by postoperative day 1 (POD1) using liquid biopsies.

Conclusions:

Cytokine and growth factor profiling, particularly using liquid biopsies on POD1, allows for early prediction of PHLF and mortality after major liver resection.
Individual regenerative potential of hepatocytes correlates with clinical outcomes.
These predictive models can guide tailored interventional strategies for patients undergoing liver surgery.