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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
Published on: August 28, 2021
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Differences in brain activity between normal and diabetic rats under isoflurane anesthesia: a resting-state
Sheng-Min Huang1, Chun-Yi Wu2, Yu-Hsin Lin3,4
1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan.
BMC Medical Imaging
|August 4, 2022
Summary
Diabetic rats show reduced brain activity, indicated by fractional amplitude of low-frequency fluctuations (fALFF), distinguishing them from healthy controls. This finding highlights neurological changes in diabetes animal models.
Area of Science:
- Neuroscience
- Endocrinology
- Medical Imaging
Background:
- Altered neural activity, measured by fractional amplitude of low-frequency fluctuations (fALFF), is observed in human diabetes patients.
- The utility of fALFF in distinguishing diabetic animal models from healthy controls under anesthesia is not well-established.
Purpose of the Study:
- To investigate changes in fALFF in a rat model of diabetes.
- To determine if fALFF can differentiate diabetic rats from healthy controls under isoflurane anesthesia.
Main Methods:
- A rat model of diabetes was induced using streptozotocin (STZ).
- Resting-state functional magnetic resonance imaging (fMRI) was employed to assess brain activity.
- fALFF was measured 4 weeks post-STZ or solvent administration.
Main Results:
- Diabetic rats exhibited significantly decreased fALFF in multiple brain regions, including the cingulate cortex, somatosensory cortex, insula, and striatum.
- These reductions in fALFF suggest aberrant neural activity in diabetic rats.
- No brain regions showed decreased fALFF in controls compared to diabetic rats.
Conclusions:
- fALFF can effectively differentiate between healthy control rats and diabetic rats.
- The findings provide valuable insights into the neurological pathophysiology of diabetes in animal models.
