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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
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Clinical Post-Transplant Lymphoproliferative Disorders

Ziba Aghsaeifard1, Reza Alizadeh2

  • 1Department of Internal Medicine, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Cardiovascular & Hematological Disorders Drug Targets
|August 5, 2022
PubMed

Post-transplant lymphoproliferative disorders (PTLDs) are characterized by hyperproliferation of B cells due to solid organ or allogeneic hematopoietic stem cell transplant. Based on histological findings, it is divided into 4 categories. Most PTLD patients are Epstein-Barr virus (EBV) positive. Additionally, aggressive immunosuppressive therapies can also lead to PTLD. Reducing immunosuppressive regimes, antivirals, monoclonal antibodies, chemotherapy, and radiotherapy are available therapeutic options, depending on the nature and phase of the disease. This review briefly highlights pathogenesis, risk factors, prevention, and therapeutic strategies regarding PTLDs.

Keywords:
Epstein-Barr virus (EBV)hematopoietic stem cellimmunosuppressionlymphomapost-transplant lymphoproliferative disorders (PTLD)transplant recipients

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