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Updated: Sep 2, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Datasets for a simulated family-based exome-sequencing study
Nirodha Epasinghege Dona1, Jinko Graham1
1Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby V5A 1S6, Canada.
Abstract:
We present simulated exome-sequencing data for 150 families from a North American admixed population, ascertained to contain at least four members affected with lymphoid cancer. These data include information on the ascertained families as well as single-nucleotide variants on the exome of affected family members. We provide a brief overview of the simulation steps and links to the associated software scripts. The resulting data are useful to identify genomic patterns and disease inheritance in families with multiple disease-affected members.
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