Related Experiment Video

Updated: Sep 2, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.5K

Exploring the antimicrobial properties of vaginal Lactobacillus crispatus against preterm birth-associated bacteria

Emmanuel Amabebe1, Noopur Bhatnagar1, Nitin Kamble2

  • 1Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.

Reproduction & Fertility
|August 5, 2022
PubMed

Insights

Lactobacillus crispatus naturally prevents Gardnerella vaginalis overgrowth, a cause of vaginal infections and premature delivery. These findings suggest new treatments for infection and preterm birth prevention.

Area of Science:

  • Microbiology
  • Obstetrics and Gynecology
  • Immunology

Background:

  • Premature delivery before 37 weeks is a significant unmet medical need.
  • Vaginal health is influenced by bacterial species, including Lactobacillus and Gardnerella vaginalis.
  • Gardnerella vaginalis overgrowth is linked to vaginal infections, increased STI risk, and premature delivery.

Purpose of the Study:

  • To investigate the interaction between Lactobacillus crispatus and Gardnerella vaginalis in vitro.
  • To identify agents from L. crispatus that inhibit G. vaginalis growth and associated immune responses.

Main Methods:

  • In vitro laboratory study of bacterial interactions.
  • Observation of L. crispatus's effect on G. vaginalis growth.
  • Analysis of biochemical compounds produced by L. crispatus.

Main Results:

  • Lactobacillus crispatus effectively cleared Gardnerella vaginalis.
  • Specific biochemical compounds produced by L. crispatus also inhibited G. vaginalis growth.
  • The interaction influenced the accompanying immune response.

Conclusions:

  • Lactobacillus crispatus possesses natural mechanisms to control Gardnerella vaginalis.
  • Biochemical compounds from L. crispatus show potential for developing treatments against vaginal infections.
  • These treatments could help prevent premature delivery linked to infection and aberrant immune responses.

More Related Videos

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip08:15

Author Spotlight: Revolutionizing Research on Vaginal Microbiome Interactions Using a Vaginal Chip

Published on: February 16, 2024

2.5K
Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria08:53

Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria

Published on: May 25, 2022

4.0K

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.3K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
149
Vagina01:26

Vagina

The vaginal canal is a tubular structure averaging about 10 cm in length that acts as the entryway to the female reproductive system and the passageway for menstrual flow and childbirth. The interior walls of the vagina exhibit concentric folds called rugae and are topped by an area known as the fornix, which connects with the protruding cervical portion of the uterus. This canal is comprised of an external fibrous layer, a muscular middle layer, and an inner lining with mucosal rugae, which...
9.6K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
7.2K
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
459