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Updated: Sep 2, 2025
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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
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Cell death in skin function, inflammation, and disease
Holly Anderton1,2, Suhaib Alqudah3,4
1Inflammation division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Melbourne, Victoria, Australia.
The Biochemical Journal
|August 5, 2022
Summary
Skin cell death is crucial for homeostasis but can cause inflammation. Inhibiting specific cell death pathways offers a promising therapeutic strategy for inflammatory skin diseases.
Area of Science:
- Dermatology and Cellular Biology
- Immunology and Inflammation
Background:
- Cell death is vital for skin homeostasis, barrier function, and immunity.
- Lytic cell death can trigger inflammation via uncontrolled release of cellular contents.
- Dysregulated cell death contributes significantly to cutaneous inflammation.
Purpose of the Study:
- To review mechanisms of skin-associated cell death.
- To discuss the role of these pathways in skin inflammation and disease.
- To explore therapeutic opportunities targeting cell death machinery.
Main Methods:
- Review of literature on skin cell death mechanisms.
- Analysis of evidence linking cell death pathways to skin inflammation.
- Discussion of therapeutic strategies targeting cell death.
Main Results:
- Identified key cell death pathways: apoptosis, necroptosis, pyroptosis, NETosis, and cornification.
- Established the dual role of cell death in skin health and disease.
- Highlighted the potential of targeting cell death for treating inflammatory skin conditions.
Conclusions:
- Targeting specific cell death pathways presents a viable therapeutic avenue for inflammatory skin diseases.
- Further research into cell death mechanisms can lead to novel treatments.
- Inhibiting excessive or aberrant cell death can restore skin homeostasis and reduce inflammation.
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