Versatile, Cheap, Readily Modifiable Sample Delivery Method for Analysis of Air-/Moisture-Sensitive Samples Using...

Area of Science:

• Analytical Chemistry
• Mass Spectrometry
• Materials Science

Background:

• Analysis of air- and moisture-sensitive samples in mass spectrometry (MS) often requires specialized techniques.
• Existing methods for Atmospheric pressure Solids Analysis Probe (ASAP) MS may involve complex sample preparation or instrument modifications.
• There is a need for simple, versatile, and cost-effective sample introduction systems for ASAP MS.

Purpose of the Study:

• To describe a novel, inexpensive, and reusable glass probe system for ASAP MS.
• To demonstrate the system's capability for analyzing air- and moisture-sensitive solid and liquid samples.
• To compare mass spectral data obtained under ambient and inert atmospheric conditions.

Main Methods:

• Fabrication of a simple, versatile, and reusable glass probe.
• Utilizing the glass probe for direct sample introduction in a commercially available, vertically loaded ASAP mass spectrometer.
• Acquisition of ASAP mass spectra for metal complexes under both air and inert atmosphere conditions.

Main Results:

• The described glass probe system enables the delivery of solid air-/moisture-sensitive samples for MS analysis.
• The system is cost-effective, versatile, readily modified, and reusable.
• Quick and easy ASAP MS analyses of sensitive solid and liquid samples were achieved without instrument modification.
• ASAP mass spectra of metal complexes were successfully obtained and compared under different atmospheric conditions.

Conclusions:

• The developed glass probe system offers a practical and efficient solution for ASAP MS analysis of sensitive compounds.
• The simplicity and reusability of the probe make it a valuable tool for routine analysis.
• The method is compatible with standard commercial ASAP MS instruments, broadening its applicability.