Study on Components with Neuroinflammation Inhibitory Activities from Croton tiglium L. var. xiaopadou
Yanping Zhang1, Minghao Sui1, Zisong Bai1
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Wenhua Road 103, Shenyang, 110016, China.
Abstract:
An undescribed tigliane diterpenoid, 13-acetyl-12,17-di-O-tiglylphorbol (1), along with thirty-three known components, were isolated from the stems of Croton tiglium L. var. xiaopadou (Euphorbiaceae). Their structures were established based on spectroscopic data and ECD spectra. Their anti-neuroinflammatory effects were evaluated in LPS-induced BV-2 microglia. Thirteen tested compounds showed significant inhibitory activities, especially compounds 10, 16, 18 and 21 exhibited an inhibitory effect with IC50 values in the range of 12.39 to 17.80 μM, which are comparable with that of the positive control (minocycline, IC50 13.92 μM).
