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Related Experiment Video

Updated: Sep 2, 2025

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Opportunistic osteoporosis screening using chest CT with artificial intelligence.

Jinrong Yang1, Man Liao2, Yaoling Wang2

  • 1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, Hubei Province, China.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|August 5, 2022
PubMed
Summary

Osteoporosis screening can be improved using vertebral attenuation values from non-enhanced chest CT scans. Artificial intelligence (AI) analysis of these values offers high diagnostic efficacy for identifying osteoporosis risk.

Keywords:
Artificial intelligence (AI)Bone mineral density (BMD)Chest computed tomography (CT)Dual-energy X-ray absorptiometry (DXA)Osteoporosis

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Area of Science:

  • Radiology and Imaging
  • Bone Health
  • Artificial Intelligence in Medicine

Background:

  • Osteoporosis is a prevalent condition with a low detection rate, leading to fractures.
  • Early detection is crucial for preventing severe consequences like osteoporotic fractures.

Purpose of the Study:

  • To evaluate the utility of thoracic and first lumbar vertebral attenuation values, measured by AI on non-enhanced chest CT, for osteoporosis screening.

Main Methods:

  • AI measured attenuation values (HU) of thoracic and lumbar vertebrae from chest CT scans.
  • Patients were categorized into normal, osteopenia, and osteoporosis groups based on DXA results.
  • Correlation between CT attenuation values and BMD, predictive ability, and diagnostic efficacy were analyzed.

Main Results:

  • Vertebral CT values decreased with age, particularly in postmenopausal women.
  • Increased CT values showed significant inverse correlation with osteopenia and osteoporosis risk.
  • Combined analysis of all thoracic vertebrae yielded higher diagnostic efficacy (AUC 0.831-0.972) than single vertebrae.

Conclusions:

  • Routine chest CT with AI enables opportunistic screening for osteopenia and osteoporosis.
  • This method efficiently identifies high-risk individuals without additional radiation exposure.
  • Improved osteoporosis detection can reduce the incidence of osteoporotic fractures.