Peripheral Interleukin-18 is negatively correlated with abnormal brain activity in patients with depression: a
Xiangdong Du1,2, Siyun Zou2, Yan Yue2,3
1Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Background:
Interleukin-18 (IL-18) may participate in the development of major depressive disorder, but the specific mechanism remains unclear. This study aimed to explore whether IL-18 correlates with areas of the brain associated with depression.
Methods:
Using a case-control design, 68 subjects (34 patients and 34 healthy controls) underwent clinical assessment, blood sampling, and resting-state functional Magnetic Resonance Imaging (fMRI). The total Hamilton depression-17 (HAMD-17) score was used to assess depression severity. Enzyme-linked immunosorbent assay (ELISA) was used to detect IL-18 levels. Rest-state fMRI was conducted to explore spontaneous brain activity.
Results:
The level of IL-18 was higher in patients with depression in comparison with healthy controls. IL-18 was negatively correlated with degree centrality of the left posterior cingulate gyrus in the depression patient group, but no correlation was found in the healthy control group.
Conclusion:
This study suggests the involvement of IL-18 in the pathophysiological mechanism for depression and interference with brain activity.
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