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Understanding and treating ejaculatory dysfunction in men with diabetes mellitus.

Ankit Desai1, Runzhi Chen1, Axel Cayetano1

  • 1Department of Andrology, Imperial Healthcare NHS Trust, London, UK.

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|August 7, 2022
PubMed
Summary
This summary is machine-generated.

Diabetes mellitus significantly impacts male sexual health, causing ejaculatory dysfunction in up to 50% of affected men. Further research is needed to understand its causes and develop effective treatments for conditions like delayed or retrograde ejaculation.

Keywords:
anejaculationautonomic neuropathydelayed ejaculationdiabetes mellitusejaculatory dysfunctionpathophysiologypremature ejaculationretrograde ejaculationsexual dysfunction

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Area of Science:

  • Endocrinology
  • Urology
  • Reproductive Medicine

Background:

  • Diabetes mellitus is a growing global health concern with increasing prevalence.
  • Male sexual dysfunction, particularly erectile dysfunction, is a recognized complication of diabetes.
  • Ejaculatory dysfunction is also prevalent in diabetic men but is less understood than erectile dysfunction.

Purpose of the Study:

  • To review the pathophysiology and treatment of ejaculatory dysfunction in men with diabetes mellitus.
  • To highlight the different types of ejaculatory disorders associated with diabetes.
  • To identify gaps in current research and suggest future directions for treatment and fertility management.

Main Methods:

  • Review of existing literature, including studies on diabetic animal models and observational human studies.
  • Analysis of pathophysiological mechanisms contributing to ejaculatory dysfunction.
  • Assessment of current evidence for treatment strategies.

Main Results:

  • Ejaculatory dysfunction affects 35%-50% of men with diabetes mellitus, encompassing premature, delayed, anejaculation, and retrograde ejaculation.
  • Pathophysiology is multifactorial, with insights gained from animal models and human studies.
  • Evidence for treating delayed and retrograde ejaculation is limited, based on low-quality studies.

Conclusions:

  • Understanding the pathophysiology of ejaculatory dysfunction in diabetes is crucial for developing targeted therapies.
  • Robust clinical trials are needed to establish effective treatments for delayed and retrograde ejaculation.
  • Further research on fertility outcomes and assisted reproductive techniques is essential for diabetic men with ejaculatory dysfunction.