Related Experiment Video
Updated: Sep 2, 2025

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
Foreword to the special issue on different approaches to force spectroscopy in the research of cell pathologies
Bartlomiej Zapotoczny1, Malgorzata Lekka1, Alessandro Podestà2
1Department of Biophysical Microstructures, Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland.
Abstract:
Atomic force microscopy (AFM) and atomic force spectroscopy (AFS) constantly develop to address the detailed description of biophysical changes occurring during cell pathologies. Although AFM is still not a clinical diagnostic tool, it provides invaluable information on the transition of cells from physiological to pathological states. This special issue on "Different approaches to force spectroscopy in the research of cell pathologies" covers some of the latest scientific reports created to bring AFM closer to diagnosing pathology in biological material.

