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Analytical methods for honeybee venom characterization.

Iouraouine El Mehdi1,2,3, Soraia I Falcão3, Saïd Boujraf1,2

  • 1Prof. Said, Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy; Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.

Journal of Advanced Pharmaceutical Technology & Research
|August 8, 2022
PubMed
Summary

Honeybee venom (HBV) shows potential pharmacological benefits, but lacks standardized quality control. This review overviews analytical methods to characterize HBV and accelerate the development of HBV-derived drugs.

Keywords:
Analytical methodsapaminenzymesmast cell degranulating peptidepeptidesvenomics

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Area of Science:

  • Venomics and drug discovery
  • Pharmacology of natural toxins

Background:

  • Honeybee venom (HBV) possesses diverse pharmacological activities, including anti-inflammatory, antibacterial, and anticancer properties.
  • HBV's primary components are melittin, phospholipase A2, and apamin, with other peptides contributing to its bioactivity.
  • Currently, no international quality standards exist for HBV due to its non-official drug status.

Purpose of the Study:

  • To provide a comprehensive overview of analytical methods for honeybee venom characterization.
  • To facilitate the standardization of HBV analysis and support the development of HBV-derived therapeutics.
  • To accelerate the discovery of new drugs based on honeybee venom components.

Main Methods:

  • Literature search conducted on PubMed, Google Scholar, and Science Direct.
  • Focused on published analytical methods for honeybee venom (HBV) characterization.
  • Review and organization of existing HBV evaluation techniques.

Main Results:

  • A significant number of analytical techniques have been developed for HBV characterization.
  • The review consolidates these methods to aid researchers in understanding HBV composition.
  • Identified methods are crucial for establishing quality standards and advancing drug discovery.

Conclusions:

  • Standardized analytical methods are essential for the quality control and therapeutic development of honeybee venom.
  • Further research and standardization will unlock the full potential of HBV in medicine.
  • This review serves as a foundational resource for future HBV research and drug development.