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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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Acute postoperative infectious endophthalmitis caused by Gram-negative organisms.
Mohamed Al-Abri1, Ahmed Al-Hinai1, Abdulrahman Al-Abri2
1Department of Ophthalmology, Sultan Qaboos University Hospital, Seeb, Sultanate of Oman.
Oman Journal of Ophthalmology
|August 8, 2022
Summary
Acute postoperative infectious endophthalmitis, often caused by Gram-positive bacteria, can also result from Gram-negative bacteria. Gram-negative infections present unique challenges and poorer visual outcomes, necessitating careful management.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Endophthalmitis is a severe intraocular inflammation, often sight-threatening.
- Postoperative acute infectious endophthalmitis is most commonly caused by bacteria.
- Gram-positive bacteria are the predominant isolates in endophthalmitis cases.
Observation:
- Gram-negative bacteria, though less common (11.5%), are associated with poorer visual outcomes.
- These pathogens are often fulminant and destructive, even with prompt treatment.
- This report details three cases of acute postoperative endophthalmitis due to Gram-negative organisms.
Findings:
- Gram-negative bacterial endophthalmitis poses significant management challenges.
- Prompt and appropriate treatment may still yield poor visual prognoses.
- Understanding the specific challenges of Gram-negative endophthalmitis is crucial.
Implications:
- Highlights the need for vigilance and tailored treatment strategies for Gram-negative endophthalmitis.
- Emphasizes the potential for severe vision loss despite medical intervention.
- Informs clinical practice regarding the management of rare but aggressive bacterial endophthalmitis cases.
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