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Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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Related Experiment Video

Updated: Sep 2, 2025

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis.

Hui-Ming Chen^1,2, Hang Li¹, Meng-Xian Lin¹

¹Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Frontiers in Genetics

|August 8, 2022

Summary

This review explores how RNA modifications, such as N6-methyladenosine (m6A), impact tumor angiogenesis. Aberrant RNA modifications are linked to cancer development and progression by regulating key factors.

Keywords:

RNA modifications angiogenesis m5C m6A tumor

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Last Updated: Sep 2, 2025

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Area of Science:

Epigenetics
Molecular Biology
Oncology

Background:

RNA modifications are crucial epigenetic regulators involved in vital biological processes like embryogenesis and stem cell differentiation.
Advancements in sequencing and antibody technologies have revealed links between RNA modifications and human diseases, including cancer.
Aberrant RNA modifications can drive tumor angiogenesis by influencing angiogenesis-related factors.

Purpose of the Study:

To review recent research on specific RNA modifications and their regulators in the context of tumor angiogenesis.
To highlight the significant role and impact of RNA modifications in the development of tumors.

Main Methods:

Literature review of cutting-edge studies.
Focus on key RNA modifications: N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), and pseudouridine (Ψ).
Analysis of the association between these modifications, their regulators, and tumor angiogenesis.

Main Results:

RNA modifications play a critical role in regulating angiogenesis-related factors.
Specific RNA modifications like m6A are implicated in promoting tumor vascularization.
The interplay between RNA modification regulators and angiogenesis is complex and multifaceted.

Conclusions:

RNA modifications are emerging as key players in tumor angiogenesis.
Targeting RNA modification pathways presents a potential therapeutic strategy for cancer treatment.
Further research is needed to fully elucidate the mechanisms by which RNA modifications influence tumor growth and metastasis.