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Progress in smartphone-enabled aptasensors.

Qurat Ul Ain Zahra1, Syed Agha Hassnain Mohsan2, Faisal Shahzad3

  • 1Biomedical Imaging Centre, University of Science and Technology of China, Hefei, Anhui, 230026, China; The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China.

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Summary

Smartphone-enabled aptasensors offer a portable and cost-effective solution for biomolecule detection, overcoming limitations of conventional devices. This review highlights advancements in smartphone biosensors for point-of-care applications.

Keywords:
AptasensorsDisease diagnosticsEnvironmental monitoringFood safetyPoint of care testingSmartphone

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Nanoscience

Background:

  • Conventional biosensors are often bulky, expensive, and difficult to use for in-situ detection.
  • Smartphones offer portability and advanced sensing capabilities for point-of-need applications.
  • Aptamers provide sensitive and selective molecular recognition for target biomolecules.

Purpose of the Study:

  • To review the concept and design of smartphone-enabled aptasensors for biosensing applications between 2017 and 2022.
  • To provide insights into fabrication strategies, operating systems, and software for these devices.
  • To discuss the merits, challenges, and future prospects of smartphone-driven aptasensors.

Main Methods:

  • Review of scientific literature from 2017-2022 on smartphone-aptasensor development.
  • Analysis of different fabrication strategies and technological components.
  • Synthesis of findings on applications, advantages, and limitations.

Main Results:

  • Smartphone-aptasensors provide user-friendly, portable, and cost-effective biosensing solutions.
  • Diverse applications in food safety, environmental monitoring, and disease diagnostics are enabled.
  • Significant progress in design, fabrication, and software integration has been achieved.

Conclusions:

  • Smartphone-aptasensors represent a promising technology for accessible point-of-care diagnostics.
  • Further development is needed to address challenges and enhance performance.
  • The technology holds potential for affordable, simple, and readily available sensing devices.