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Updated: Jun 5, 2026
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
A wearable paper-based SGR/MCC microneedle array sensor for continuous glucose monitoring
Joseph Benjamin Holman1, Talifhani Mushiana2, Chen Yang3
1Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, and Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Microsystems & Nanoengineering
|June 3, 2026
Summary
This study introduces a novel microneedle (MN) array on paper for continuous glucose monitoring (CGM), offering a comfortable, cost-effective, and eco-friendly solution for diabetes management.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Continuous glucose monitoring (CGM) is crucial for diabetes management.
- Current microneedle (MN) technologies for glucose sensing face practical limitations.
Purpose of the Study:
- To develop a disposable, paper-based microneedle array for electrochemical glucose sensing in interstitial fluid (ISF).
- To integrate the MN array with reusable electronics and a mobile app for practical CGM.
Main Methods:
- Fabrication of a solid MN array using a biocompatible resin and microcrystalline cellulose composite on a flexible paper substrate.
- Conversion of MN arrays into conductive electrodes via graphene ink coating for electrochemical sensing.
- Integration into a wearable patch for continuous ISF glucose monitoring.
Main Results:
- Demonstrated excellent analytical performance in ex vivo and in vivo models.
- Achieved high sensitivity, selectivity against interferents, and robust stability.
- Validated the system for monitoring glucose in porcine plasma, artificial skin, and mice.
Conclusions:
- Presents a simple, cost-effective, and eco-friendly approach for wearable electroanalytical devices.
- Paves the way for practical and accessible continuous glucose monitoring.
- Highlights the potential of paper-based MN technology for biomedical applications.
