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Generation of cost-effective MXene@polydopamine-decorated chitosan nanofibrous wound dressing for promoting wound
Hongbin Li1, Jiliang Dai2, Xiaotong Yi3
1MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China; College of Light Industry and Textile, Qiqihar University, Qiqihar, Heilongjiang 161000, PR China.
Abstract:
Herein, we designed and fabricated a MXene@polydopamine (MXene@PDA)-decorated chitosan non-woven fabric (M-CNF) hemostatic dressing with super hydrophilic properties for wound repair and regeneration. The M-CNF exhibit excellently wettability characteristics which can rapidly absorb water from blood. Moreover, M-CNF with 15 mg/mL MXene@PDA (M-CNF-15) show better antibacterial performance, excellent blood-clotting performance, better blood cell and platelet adhesion ability than CNF, displaying both active and passive hemostatic mechanisms to accelerate blood clotting in mouse-liver injury model. In addition, the M-CNF-15 also shows better wound healed performance than Tegaderm™ film in a full-thickness skin defect model, and further demonstrating that the MXene@PDA can promote fibrinogen reformation the at the initial phases of the wound healing process. Therefore, this strategy for designing and manufacturing of multi-functional M-CNF wound dressing will have great potential for active local hemostasis and wound repair and regeneration.
