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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

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Pediatric Plasma Cell Neoplasms: A Population-Based Study.

Pierre Loap¹, Marguerite Vignon², Didier Bouscary²

¹Institut Curie, Department of Radiotherapy, Paris, France.

Clinical Lymphoma, Myeloma & Leukemia

|August 8, 2022

Summary

This summary is machine-generated.

Pediatric plasma cell neoplasms are rare, with plasmacytomas being more common than myeloma. This study highlights unique demographic features and poorer outcomes for pediatric plasma cell myeloma.

Keywords:

Cancer epidemiology Pediatric patients Plasma cell myeloma Plasmacytoma SEER database

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Published on: March 26, 2018

Area of Science:

Hematology
Pediatric Oncology
Cancer Epidemiology

Background:

Plasma cell neoplasms are rare in children, with limited understanding of their demographics and outcomes.
Existing data on pediatric plasma cell neoplasms is scarce, necessitating population-based studies.

Purpose of the Study:

To conduct a comprehensive analysis of pediatric plasma cell neoplasms.
To describe the demographic characteristics and clinical outcomes of this rare pediatric malignancy.

Main Methods:

Utilized the United States Surveillance, Epidemiology, and End Results (SEER) program database (2000-2018).
Included pediatric patients (<20 years) diagnosed with malignant plasma cell neoplasms.
Analyzed data on neoplasm type, demographics, site, and survival outcomes.

Main Results:

Incidence rate in pediatric population is 0.06 per 1,000,000 person-years.
Plasmacytomas (solitary extraosseous and bone) predominated over plasma cell myeloma.
Hispanic patients and females were disproportionately represented; head and neck region was a common site for plasmacytomas.
Five-year survival rates were significantly lower for pediatric plasma cell myeloma (36.5%) compared to plasmacytoma (88.2%).

Conclusions:

Pediatric plasma cell neoplasms are rare and distinct from adult forms.
Characterized by a predominance of plasmacytomas, female gender, and Hispanic origin.
Pediatric plasma cell myeloma carries a poor prognosis, underscoring the need for further research and targeted therapies.