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Reconsidering PARP inhibitor-radiotherapy combinations in the stereotactic era

Donato Pezzulla1, Amelia Barcellini2, Chiara Cassani3

  • 1Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|June 24, 2026
PubMed
Abstract

No abstract available in PubMed .

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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