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Updated: Sep 2, 2025
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Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
Published on: August 18, 2023
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Association between constipation and the development of asthma: a meta-analysis
Lu Liu1, Xiangli Zhang2, Zhengdong Jiang3
1Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, No. 256, West Youyi Road, Xi'an, Shaanxi, 710068, People's Republic of China. liulu290@126.com.
Summary
Constipation may increase the risk of developing wheezing or asthma later in life. This meta-analysis suggests a significant association between childhood constipation and later respiratory symptoms.
Area of Science:
- Pediatric Health
- Respiratory Medicine
- Gastroenterology
Background:
- Constipation is a common childhood issue.
- A potential link between constipation and respiratory conditions like wheezing and asthma has been proposed but remains debated.
- This study investigates the association between constipation and the risk of wheezing/asthma.
Purpose of the Study:
- To systematically evaluate the relationship between constipation and the risk of developing wheezing or asthma.
- To synthesize evidence from existing studies to clarify this association.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Embase, and Web of Science databases.
- Data from eligible studies published between 1955 and January 2022 were independently extracted and quality assessed by two reviewers.
- Results were pooled using appropriate meta-analysis models (fixed-effects or random-effects).
Main Results:
- Three studies with a total of 178,661 participants were included in the meta-analysis.
- Constipation was found to be significantly associated with an increased risk of wheezing/asthma in later life (RR = 2.02, 95% CI = 1.24-3.29, P < 0.01).
Conclusions:
- The findings suggest a positive association between constipation and the subsequent development of wheezing/asthma.
- Further high-quality, prospective studies are needed to confirm this association and explore potential confounding factors.
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