Protocol for spike-triggered closed-loop auditory stimulation during sleep in patients with epilepsy
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Updated: Sep 2, 2025
Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
Published on: November 12, 2019
Hong-Viet V Ngo1, Jan Born2, Jens G Klinzing3
1Department of Psychology, University of Lübeck, 23562 Lübeck, Germany; Center for Brain, Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Abstract:
Several epilepsies are characterized by interictal spikes in the electroencephalogram occurring preferentially during sleep. We present a closed-loop auditory stimulation protocol with potential for treating sleep epilepsies. We describe the pre-sleep preparations, sleep recordings, the auditory stimulation, in which tones are triggered upon spike detection, and post-sleep procedures. This protocol has been shown to decrease likelihood and amplitude of subsequent spikes in patients with BECTS (Benign epilepsy with centrotemporal spikes) and can be applied to study non-pharmacological treatments of sleep epilepsies. For complete details on the use and execution of this protocol, please refer to Klinzing et al. (2021).
