Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

3.7K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.7K
Glial Cells01:04

Glial Cells

88.4K
Overview
88.4K
The Blood-brain Barrier00:49

The Blood-brain Barrier

48.2K
Overview
48.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adiponectin Fortifies White Matter After Chronic Hypoperfusion-Induced Vascular Dementia.

Stroke·2026
Same author

Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice.

PNAS nexus·2026
Same author

1,3-Dicarbonyl Rhodamines for Live-Cell Single-Molecule Super-Resolution Imaging.

Angewandte Chemie (International ed. in English)·2026
Same author

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration.

Nature·2026
Same author

Consensus Review of Perioperative Immune Modulation for Endovascular Thrombectomy Following Ischemic Stroke.

Stroke·2026
Same author

Monocyte-derived macrophages and their roles in ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Post-Ischemic Sodium Glucose Cotransporter Inhibition Attenuates Ischemia-Reperfusion Injury via Regulation of Mitochondrial Membrane Potential.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Glymphatic System Dysfunction and Neurological Disorders: From Mechanisms to Therapeutic Strategies.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Toll Like Receptor 4 (TLR4) in Neuroinflammation: From Acute Hemorrhagic Stroke to Chronic Neurodegeneration.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Mechanical Compaction Alters Microstructural and Magnetic Resonance Imaging Properties of Acute Ischemic Stroke Clots.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
See all related articles

Related Experiment Video

Updated: Sep 2, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.9K

Microglia: Active participants in brain capillary function.

Connor Dufort1, Yangfan Wang1, Xiaoming Hu1,2

  • 1Pittsburgh Institute of Brain Disorders and Recovery, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|August 9, 2022
PubMed
Summary
This summary is machine-generated.

Researchers identified capillary-associated microglia (CAM) in the mouse brain. These specialized microglia play a significant role in regulating cerebral blood flow, offering new insights into neurovascular health.

Keywords:
Capillarycerebral blood flowmicrogliapericytesvascular regulation

More Related Videos

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.1K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.7K

Related Experiment Videos

Last Updated: Sep 2, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

9.9K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.1K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Vascular Biology

Background:

  • Microglia are the primary immune cells of the central nervous system.
  • The specific roles of microglia positioned along brain capillaries remain largely uncharacterized.
  • Understanding the neurovascular unit is crucial for addressing cerebrovascular diseases.

Purpose of the Study:

  • To characterize a distinct population of capillary-associated microglia (CAM) in the healthy mouse brain.
  • To investigate the function of CAMs in the regulation of cerebral blood flow.
  • To explore the interactions of CAMs within the neurovascular unit.

Main Methods:

  • Longitudinal intravital imaging of brain vasculature and CAMs in live mice.
  • Characterization of CAM morphology and location relative to capillaries.
  • Analysis of CAM involvement in dynamic changes in cerebral blood flow.

Main Results:

  • A population of CAMs with cell bodies situated along small brain blood vessels was identified.
  • Longitudinal imaging revealed the dynamic behavior of CAMs in relation to blood flow.
  • Evidence suggests a significant role for CAMs in the regulation of cerebral blood flow.

Conclusions:

  • Capillary-associated microglia represent a specialized functional subset of brain microglia.
  • CAMs are integral components of the neurovascular unit, influencing vascular dynamics.
  • Further research into CAMs may yield new therapeutic targets for cerebrovascular diseases.