Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

657
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
657
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

847
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
847
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

276
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
276
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

979
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
979
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.8K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

55
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
55

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficacy and safety of olezarsen versus volanesorsen for familial chylomicronemia syndrome: a matching-adjusted indirect comparison.

Journal of comparative effectiveness research·2026
Same author

In Vivo Base Editing of <i>PCSK9</i> with VERVE-102 for Hypercholesterolemia.

The New England journal of medicine·2026
Same author

Global survey of genetic testing methods for familial hypercholesterolemia. A study and recommendations from the EAS FHSC registry.

European journal of preventive cardiology·2026
Same author

Interrelationship Between Socioeconomic Status, Depression, and Neuropathy in People with Diabetes: A Cross-Sectional Study.

Journal of clinical medicine·2026
Same author

Antioxidant Role of High-Density Lipoprotein.

Antioxidants (Basel, Switzerland)·2026
Same author

Impacts of the Urban Wastewater Discharges on the Indus River Basin: Water Quality Assessment and GIS Pollution Mapping.

Water environment research : a research publication of the Water Environment Federation·2026

Related Experiment Video

Updated: Sep 2, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K

Lipoprotein (a) in familial hypercholesterolaemia.

Paul N Durrington1, Bilal Bashir1,2, Deepak Bhatnagar1

  • 1Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester.

Current Opinion in Lipidology
|August 9, 2022
PubMed
Summary

Familial hypercholesterolemia often raises lipoprotein (a) levels, but its specific contribution to atherosclerotic cardiovascular disease risk requires further investigation with targeted therapies.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.4K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

Related Experiment Videos

Last Updated: Sep 2, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.2K
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

11.4K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Genetics

Background:

  • The role of lipoprotein (a) [Lp(a)] in atherogenesis and its association with familial hypercholesterolemia (FH) has been debated.
  • A clear mechanism linking Lp(a) to low-density lipoprotein (LDL) receptor-mediated catabolism has been lacking.
  • The independent contribution of Lp(a) to the elevated atherosclerotic cardiovascular disease (ASCVD) risk in FH is uncertain.

Purpose of the Study:

  • To review existing evidence on the relationship between Lp(a) and FH.
  • To clarify the extent to which Lp(a) contributes to ASCVD risk in FH patients.
  • To discuss the potential therapeutic implications of targeting Lp(a) in FH.

Main Methods:

  • Review of current scientific literature and evidence.
  • Analysis of mechanisms involved in Lp(a) regulation in FH.
  • Discussion of clinical implications and future research directions.

Main Results:

  • Inheriting FH increases the likelihood of elevated Lp(a) levels, potentially via increased hepatic production influenced by PCSK9 and apolipoprotein E.
  • The precise contribution of elevated Lp(a) to ASCVD risk in FH remains controversial.
  • Emerging therapies targeting Lp(a) may be most effective in individuals with the highest Lp(a) levels, such as those with FH.

Conclusions:

  • FH is strongly associated with increased Lp(a) levels.
  • Further research, particularly using Lp(a)-lowering drugs, is needed to definitively test the contribution of Lp(a) to ASCVD risk in the context of high LDL cholesterol in FH.
  • Individuals with FH may represent a key population for evaluating novel Lp(a)-targeted therapies.