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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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MXene-modified molecularly imprinted polymers as an artificial bio-recognition platform for efficient electrochemical
Ayushi Singhal1,2, Shalu Yadav1,2, Mohd Abubakar Sadique1,2
1CSIR-Advanced Materials and Processes Research Institute (AMPRI), Hoshangabad Road, Bhopal - 462026, MP, India. khan.raju@ampri.res.in.
Physical Chemistry Chemical Physics : PCCP
|August 9, 2022
Summary
MXene-modified molecularly imprinted polymers (MIPs) offer enhanced electrochemical sensing platforms. This review explores MXene-MIP nanocomposites for sensitive, selective, and stable bio-free sensing, advancing point-of-care testing.
Area of Science:
- Electrochemistry
- Materials Science
- Nanotechnology
Background:
- Molecularly imprinted polymers (MIPs) are cost-effective artificial bio-recognition elements for electrochemical sensors.
- MIPs offer advantages in affordability, processability, and scalability over traditional bio-recognition elements.
- Challenges remain in MIP stability and sensitivity for advanced sensing applications.
Purpose of the Study:
- To review state-of-the-art MXene-modified MIP electrochemical sensing platforms.
- To highlight MXene-MIP nanocomposites as a solution for enhancing MIP stability and sensitivity.
- To explore the potential of these advanced materials for bio-free sensing systems and point-of-care testing (POCT).
Main Methods:
- Modification of MIPs with electro-active nano-systems, specifically MXene.
- Fabrication of MXene-MIP nanocomposite-based electrochemical sensors.
- Review of literature on the performance and applications of these novel sensing platforms.
Main Results:
- MXene modification significantly enhances the efficiency, stability, and sensitivity of MIP-based electrochemical sensors.
- MXene-MIP nanocomposites enable sensitive and selective detection of health monitoring markers.
- These platforms offer a promising route towards robust, bio-free sensing systems.
Conclusions:
- MXene-MIP nanocomposites represent a next-generation sensing platform with improved performance over pristine MIPs.
- These advanced materials address key limitations of MIPs, paving the way for high-performance electrochemical sensors.
- The developed sensing platforms show significant potential for point-of-care testing (POCT) applications in health monitoring.
