Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Cell Migration01:19

Cell Migration

5.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.1K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

2.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
Cancer02:18

Cancer

49.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
49.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic health impact of cancer-associated extracellular vesicles and particles.

Nature reviews. Cancer·2026
Same author

Rewiring dormancy.

Nature cell biology·2026
Same author

Breaking Barriers in Leptomeningeal Disease: A SNO-ASCO Consensus Review on Clinical Trial Design and Basic Science Integration.

Neuro-oncology·2026
Same author

Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting.

medRxiv : the preprint server for health sciences·2026
Same author

Implementation of electronic patient-reported outcome measures in hemodialysis: Findings from a matched cohort study.

The journal of vascular access·2026
Same author

Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity.

Cancer cell·2026
Same journal

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Cancer cell·2026
Same journal

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same journal

Intratumoral B cells under stress.

Cancer cell·2026
Same journal

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.

Cancer cell·2026
Same journal

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same journal

OpenIO: An open framework for AI-native immunotherapy.

Cancer cell·2026
See all related articles

Related Experiment Video

Updated: Sep 2, 2025

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

1.2K

Metastasis.

David Lyden, Cyrus M Ghajar, Ana Luísa Correia

    Cancer Cell
    |August 9, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Metastasis, a primary cause of cancer mortality, presents significant challenges in oncology. Experts discuss current knowledge gaps and future research directions in understanding tumor cell dissemination and outgrowth.

    More Related Videos

    Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
    07:31

    Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

    Published on: May 24, 2016

    17.7K
    Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
    08:54

    Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

    Published on: May 20, 2020

    9.2K

    Related Experiment Videos

    Last Updated: Sep 2, 2025

    Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
    05:23

    Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

    Published on: July 7, 2023

    1.2K
    Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
    07:31

    Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

    Published on: May 24, 2016

    17.7K
    Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells
    08:54

    Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

    Published on: May 20, 2020

    9.2K

    Area of Science:

    • Oncology
    • Cancer Biology
    • Cellular Biology

    Background:

    • Metastasis is the leading cause of cancer-related mortality.
    • Understanding the biological mechanisms of cancer cell spread and growth is crucial.
    • Key challenges include tumor cell dormancy, resistance to therapy, and immune evasion.

    Purpose of the Study:

    • To explore the unknowns in cancer metastasis.
    • To highlight recent advances in understanding metastasis.
    • To identify opportunities for future research in cancer metastasis.

    Main Methods:

    • Expert opinion and discussion synthesis.
    • Review of current literature on cancer metastasis.
    • Identification of critical research questions.

    Main Results:

    • Gaps in knowledge regarding tumor cell dormancy and resistance.
    • Insights into tumor cell interactions with the microenvironment.
    • Identification of promising areas for therapeutic development.

    Conclusions:

    • Further research is needed to elucidate the complex processes of metastasis.
    • Targeting metastatic pathways offers potential for improved cancer treatment.
    • Interdisciplinary collaboration is essential to overcome challenges in oncology.