Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A
Daniel E Weiner1, Christine K Liu2, Shiyuan Miao1
1Department of Medicine, Tufts Medical Center, Boston, Massachusetts.
Summary
Exercise training improved physical function in older adults with advanced chronic kidney disease (CKD). This 12-month program was safe and beneficial for patients with CKD stages 3b-4 and comorbidities.
Area of Science:
- Nephrology
- Geriatrics
- Exercise Physiology
Background:
- Uncertainty exists regarding the efficacy of long-term exercise in mitigating physical functional decline in older adults with advanced chronic kidney disease (CKD) and comorbidities.
- Older adults with advanced CKD often experience significant physical functional loss, impacting their quality of life.
Purpose of the Study:
- To evaluate the safety and efficacy of a 12-month supervised exercise training program in improving physical function in older adults with advanced CKD and comorbidities.
- To assess the impact of exercise on cardiorespiratory fitness, gait, and other functional measures.
Main Methods:
- A multicenter, parallel-group, randomized controlled trial involving 99 adults aged 55 years and older with estimated glomerular filtration rate (eGFR) between 15-45 mL/min/1.73 m².
- Participants were randomized to either 12 months of supervised aerobic and muscle-strengthening exercise or a health education control group.
- Primary outcomes included cardiorespiratory fitness (Vo₂peak) and 6-minute walk test distance at 6 and 12 months.
Main Results:
- Exercise training was well-tolerated with no excess adverse events.
- While aerobic capacity showed a significant improvement at 6 months, this was not sustained at 12 months.
- Significant improvements were observed in 6-minute walk distance and the Timed Up and Go Test in the exercise group compared to the control group.
Conclusions:
- A 12-month in-center supervised exercise program incorporating aerobic and resistance training is safe for older adults (≥55 years) with advanced CKD (stages 3b-4) and high comorbidity.
- The program demonstrated improvements in physical functioning, specifically in gait and mobility, suggesting a potential benefit for this patient population.
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