Race and prostate cancer: genomic landscape
Camilo Arenas-Gallo1, Jude Owiredu2, Ilon Weinstein1
1Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Nature Reviews. Urology
|August 9, 2022
Summary
Genomic research has revealed prostate cancer subtypes and drivers, but its role in racial disparities remains unclear. Further inclusive genomic studies are crucial for understanding these differences.
Area of Science:
- Oncology
- Genomics
- Cancer Research
Background:
- Significant advancements in understanding prostate cancer genomics over the last two decades.
- Large-scale integrative genomics have characterized the genetic and epigenetic landscape.
- Identification of molecular drivers has advanced, with some variations noted across different races.
Purpose of the Study:
- To review insights into the genomic pathogenesis of prostate cancer.
- To define molecular subclasses based on integrated genomic data.
- To explore the role of genomics in explaining racial disparities in prostate cancer outcomes.
Main Methods:
- Utilizing large-scale integrative genomics approaches.
- Analyzing genetic alterations, gene expression patterns, and methylation profiles.
- Reviewing existing literature on prostate cancer genomics and racial disparities.
Main Results:
- Characterization of the genetic and epigenetic landscape of prostate cancer.
- Definition of distinct molecular subclasses.
- Identification of several molecular drivers, some race-specific.
Conclusions:
- Genomic insights have advanced prostate cancer research but do not fully explain racial outcome disparities.
- Further collaborative genomic studies are essential.
- Addressing underrepresentation of minority populations in genomic studies is critical for future progress.
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