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Updated: Sep 2, 2025

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)
Published on: March 16, 2012
Holds enable one-shot reciprocal exchange
Marcus Frean1, Stephen Marsland2
1School of Engineering and Computer Science, Victoria University of Wellington, Wellington, New Zealand.
Abstract:
Strangers routinely cooperate and exchange goods without any knowledge of one another in one-off encounters without recourse to a third party, an interaction that is fundamental to most human societies. However, this act of reciprocal exchange entails the risk of the other agent defecting with both goods. We examine the choreography for safe exchange between strangers, and identify the minimum requirement, which is a shared hold, either of an object, or the other party; we show that competing agents will settle on exchange as a local optimum in the space of payoffs. Truly safe exchanges are rarely seen in practice, even though unsafe exchange could mean that risk-averse agents might avoid such interactions. We show that an 'implicit' hold, whereby an actor believes that they could establish a hold if the other agent looked to be defecting, is sufficient to enable the simple swaps that are the hallmark of human interactions and presumably provide an acceptable trade-off between risk and convenience. We explicitly consider the particular case of purchasing, where money is one of the goods.
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