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rTMS for poststroke pusher syndrome: study protocol for a randomised, patient-blinded controlled clinical trial
Lijiao Meng1,2, Raymond C C Tsang3, Yanlei Ge1,2
1Rehabilitation Medicine Center, Sichuan University West China Hospital, Chengdu, Sichuan, China.
BMJ Open
|August 10, 2022
Summary
This study investigates if repetitive transcranial magnetic stimulation (rTMS) can effectively treat poststroke pusher syndrome (PS). The research aims to reduce pushing behavior and improve motor recovery in stroke patients with PS.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Neuroscience
Background:
- Poststroke pusher syndrome (PS) is prevalent, leading to prolonged rehabilitation and challenges for clinicians.
- Repetitive transcranial magnetic stimulation (rTMS) is a recommended neuromodulation technique for stroke rehabilitation, but its efficacy for PS is unexamined.
Purpose of the Study:
- To assess the efficacy of a specific rTMS program for reducing pushing behavior in PS patients.
- To evaluate rTMS's impact on motor recovery and mobility enhancement in PS.
- To determine the safety profile of rTMS for individuals with PS.
Main Methods:
- A randomized, patient and assessor blinded, sham-controlled trial involving 34 eligible PS patients.
- Intervention group received rTMS, control group received sham rTMS for 3 weeks.
- Primary outcome: pushing behavior (Burke Lateropulsion Scale, Scale for Contraversive Pushing). Secondary outcomes: motor function, mobility, and adverse events.
Main Results:
- Data analysis using repeated-measures ANOVA with significance at p < 0.05.
- Assessments conducted at baseline, and at 1, 2, and 3 weeks post-intervention.
Conclusions:
- The study protocol is approved by the Biomedical Ethics Committee of West China Hospital, Sichuan University.
- Trial findings will be disseminated through peer-reviewed publications.
