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Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
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Published on: October 20, 2023

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Siglec receptors as new immune checkpoints in cancer

Michal A Stanczak1, Heinz Läubli2

  • 1The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD, 21287, USA.

Molecular Aspects of Medicine
|August 10, 2022
PubMed

Insights

Siglec receptors show promise as novel immune checkpoints for cancer immunotherapy, offering new targets to overcome resistance to current treatments and improve patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer immunotherapy, including immune checkpoint inhibitors and cellular therapies, has advanced treatment but faces resistance in many cancers.
  • Overcoming resistance necessitates novel therapeutic strategies and rational combination approaches.

Purpose of the Study:

  • To review emerging evidence positioning Siglec receptors as novel immune checkpoints in cancer.
  • To discuss the mechanisms of action of Siglec receptors in cancer immunology.
  • To summarize current strategies targeting Siglec receptors and their sialoglycan ligands.

Main Methods:

  • Literature review of experimental evidence.
  • Analysis of Siglec receptor function in cancer.
  • Examination of therapeutic targeting strategies.

Main Results:

  • Growing evidence supports Siglec receptors as critical regulators of anti-cancer immunity.
  • Siglec receptors and their sialoglycan ligands represent potential targets for modulating immune responses in cancer.

Conclusions:

  • Siglec receptors are emerging as promising new targets for cancer immunotherapy.
  • Targeting Siglec receptors may offer a strategy to overcome resistance to existing immunotherapies.
Keywords:
Cancer immunotherapyImmune checkpoint inhibitorInnate immunityMonoclonal antibodiesSialic acidSialidaseT cells

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