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Molecular basis of MHC I quality control in the peptide loading complex

Alexander Domnick1, Christian Winter1, Lukas Sušac1

  • 1Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.

Nature Communications
|August 10, 2022
PubMed
Summary

The peptide loading complex (PLC) stabilizes peptide-receptive Major Histocompatibility Complex class I (MHC I) molecules. Glycan processing and peptide loading are coupled, initiating adaptive immunity.

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