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Cardiovascular Complications in Systemic Lupus Erythematosus
Rahmah Alghareeb1, Afshan Hussain2, Marvi V Maheshwari3
1College of Medicine, University of Baghdad, Baghdad, IRQ.
Cureus
|August 11, 2022
Summary
Systemic lupus erythematosus (SLE) increases cardiovascular risks, including premature atherosclerosis and heart conditions. This review explores SLE
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease impacting multiple organs.
- SLE disproportionately affects young women, with increasing prevalence and mortality.
- Cardiovascular complications are a major cause of mortality in SLE patients.
Purpose of the Study:
- To review the shared pathophysiology between SLE and cardiovascular disease (CVD).
- To identify common cardiac risks and events associated with SLE.
- To discuss current management strategies for SLE-related cardiac issues.
Main Methods:
- Literature review focusing on pathophysiology, risk factors, and clinical events.
- Analysis of studies correlating SLE with cardiovascular complications.
- Synthesis of information on therapeutic interventions.
Main Results:
- SLE shares pathophysiological pathways with CVD, increasing risks like atherosclerosis, endocarditis, and valve disease.
- Metabolic syndrome and dyslipidemia are frequently associated with SLE, exacerbating cardiac risks.
- Certain SLE medications can negatively impact cardiac health.
Conclusions:
- Understanding the interplay between SLE and CVD is crucial for patient outcomes.
- Comprehensive management addressing both SLE activity and cardiovascular risk factors is essential.
- Further research into targeted therapies for SLE-associated cardiac disease is warranted.
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