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Association of Adult Atopic Dermatitis Severity With Decreased Physical Activity: A Cross-sectional Study
Gabrielle Schwartzman1, Donald Lei2, Adnan Ahmed2
1From the Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Dermatitis : Contact, Atopic, Occupational, Drug
|August 11, 2022
Summary
Adults with atopic dermatitis (AD) experience less physical activity (PA) due to severe itch and disease burden. Managing AD symptoms is crucial for improving daily activity levels in patients.
Area of Science:
- Dermatology
- Public Health
- Exercise Science
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by intense pruritus, impacting patients' quality of life.
- Associated symptoms like pain, sleep disturbance, depression, and anxiety in AD can significantly reduce physical activity (PA).
- Understanding the relationship between AD severity, itch, and PA is vital for comprehensive patient care.
Purpose of the Study:
- To investigate the impact of atopic dermatitis (AD) disease severity and itch on physical activity (PA) levels in adult patients.
- To identify specific AD severity metrics associated with limitations in light, moderate, and vigorous PA.
- To analyze the influence of itch on different intensities of physical activity.
Main Methods:
- Prospective, practice-based study involving 955 adult patients with atopic dermatitis.
- Utilized multivariable logistic regression to control for demographic and clinical factors.
- Assessed disease severity using patient-reported outcomes (PtGA, POEM, IGA) and objective measures (EASI, O-SCORAD), alongside itch severity questionnaires.
Main Results:
- Higher patient-reported AD severity (PtGA, POEM, EASI, IGA) and objective measures (O-SCORAD) were significantly associated with reduced light, moderate, and vigorous PA due to itch.
- Itch severity, measured by PROMIS Itch Questionnaire PA T-scores, was inversely associated with all levels of PA.
- Specific AD severity indices correlated with limitations in performing PA for at least 30 minutes weekly.
Conclusions:
- Adult patients with more severe atopic dermatitis experience decreased physical activity primarily because of itch.
- The findings underscore the importance of effectively managing AD symptoms, particularly itch, to enhance physical activity and overall well-being.
- Interventions targeting itch control in AD may lead to significant improvements in patients' ability to engage in regular physical activity.
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