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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Adipose Tissue Dysfunction: Impact on Metabolic Changes?
Jennifer Beatriz Silva Morais1, Thaline Millany da Silva Dias1, Bruna Emanuele Pereira Cardoso1
1Nutrition, Universidade Federal do Piaui, Teresina, Brazil.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|August 11, 2022
Summary
Adipose tissue dysfunction, driven by exceeding expansion capacity, leads to ectopic fat accumulation and inflammation, contributing to metabolic disorders like obesity. Understanding these mechanisms is key to mitigating obesity
Area of Science:
- Metabolic Physiology
- Endocrinology
- Obesity Research
Background:
- Adipose tissue, a dynamic endocrine organ, regulates metabolic homeostasis through biologically active compounds.
- Exceeding adipose tissue expansion capacity causes dysfunction and ectopic fat accumulation, linked to obesity and metabolic disorders.
- Ectopic lipid accumulation triggers local inflammation and insulin resistance, exacerbating metabolic dysfunction.
Approach:
- Comprehensive literature review across major scientific databases (PubMed, Web of Science, Scopus, Cochrane).
- Inclusion of diverse study types: clinical trials, animal/human experimental studies, case-control, case series, letters, and reviews.
- No restrictions on publication year, ensuring a broad and current research scope.
Key Points:
- Adipose tissue structure and expandability are crucial for metabolic health.
- Adipocyte dysfunction and ectopic fat deposition drive inflammation and insulin resistance.
- Overnutrition-induced inflammation in white adipose tissue promotes chronic low-grade inflammation.
Conclusions:
- Understanding the molecular mechanisms of adipose tissue dysfunction is vital for addressing obesity.
- Targeting adipose tissue dysfunction can mitigate the negative metabolic consequences of obesity.
- Further research into adipose tissue biology is essential for developing effective metabolic disorder interventions.
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