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Related Experiment Video

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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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Published on: May 17, 2024

Benign Neurogenic Tumors.

Jeffrey M Farma¹, Andrea S Porpiglia¹, Elaine T Vo¹

¹Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

The Surgical Clinics of North America

|August 11, 2022

Summary

This summary is machine-generated.

Neurogenic tumors originate from nervous system cells and are classified by their cell type. While often benign, surgical intervention requires careful preoperative evaluation, particularly for tumors secreting catecholamines.

Keywords:

Benign neurogenic tumors Neurofibroma Paraganglioma Pheochromocytoma Schwannoma

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Translational Orthotopic Models of Glioblastoma Multiforme

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Published on: February 17, 2023

Area of Science:

Neuro-oncology
Pathology of the nervous system

Background:

Neurogenic tumors originate from various cells within the nervous system.
These tumors are categorized based on their cell of origin, including ganglion cells, paraganglion cells, and nerve sheath cells.
Examples include neuroblastomas, pheochromocytomas, schwannomas, and neurofibromas.

Purpose of the Study:

To provide a classification of neurogenic tumors based on cellular origin.
To highlight the clinical presentation and management considerations for these tumors.

Main Methods:

Review of neurogenic tumor classification based on cell of origin.
Discussion of clinical presentation, including local compressive symptoms.
Emphasis on preoperative workup, especially for catecholamine-secreting tumors.

Main Results:

Neurogenic tumors encompass a range of neoplasms derived from different neural cell types.
Most neurogenic tumors are benign but can cause significant local symptoms.
Catecholamine-secreting tumors necessitate specific preoperative assessments.

Conclusions:

Understanding the cell of origin is crucial for classifying neurogenic tumors.
Surgical treatment is indicated for symptomatic neurogenic tumors.
Thorough preoperative evaluation is essential for safe and effective management, particularly for hormonally active tumors.