Ambulatory and exercise-induced blood pressure responses in type I diabetic patients and normal subjects

We evaluated the ambulatory blood pressure (BP) readings during daily activities and compared the values with the casual office BPs in 12 type I diabetic patients and 12 age-matched, non-diabetic normal controls. The BP responses to 750 kpm/min exercise work load on bicycle ergometer were also evaluated in all the subjects. The mean ambulatory BPs were significantly higher in the diabetic patients compared with non-diabetic subjects. However, the ambulatory and casual office BPs were remarkably similar in each group. Mean peak exercise BPs were higher in the diabetics, but significantly so for diastolic BP (P less than 0.05) and mean arterial pressure (MAP) (P less than 0.01). The mean ambulatory MAP significantly correlated with the casual office MAP in both the diabetics (r = 0.75, P less than 0.005) and non-diabetics (r = 0.58, P less than 0.02). A significantly positive relationship (r = 0.87, P less than 0.001) existed between the ambulatory and peak exercise MAP in the diabetics, but not in the non-diabetic subjects. The mean peak exercise BP responses were significantly (P less than 0.01) higher in the diabetic patients with proliferative retinopathy vs. those with non-proliferative retinopathy. We conclude that casual office BPs reflect the ambulatory values in both diabetics and non-diabetics. Exaggerated BP responses to exercise are found in diabetic patients, especially in the presence of proliferative retinopathy. These findings are suggestive of possible defects in the cardiovascular, autonomic and autoregulatory mechanisms that maintain a normal MAP during daily stresses and exercise in the diabetic patients.