Related Experiment Video
Updated: Jun 22, 2026

Preparing Adherent Cells for X-ray Fluorescence Imaging by Chemical Fixation
Published on: March 12, 2015
Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for
Felipe A Calvo1, Javier Serrano1, Mauricio Cambeiro1
1Department of Oncology, Clínica Universidad de Navarra, 28027 Madrid, Spain.
Intraoperative electron radiation therapy (IOeRT) is an evidence-based cancer treatment. Analysis of over 19,000 patients shows IOeRT offers variable local control, guiding future FLASH studies.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Intraoperative electron radiation therapy (IOeRT) has a 4-decade history in cancer treatment.
- Electron beams offer potential for FLASH (femtosecond) radiation delivery.
Purpose of the Study:
- To review clinical outcomes of IOeRT across various cancer types.
- To inform guidelines and identify candidates for advanced radiation techniques like FLASH.
Main Methods:
- Bibliometric search of 116 publications (1982-2020) covering 19,148 patients.
- Analysis of radiobiological strategies: boost versus exclusive IOeRT.
- Review of clinical outcomes for IOeRT doses (10-25 Gy).
Main Results:
- IOeRT evaluated in soft tissue sarcoma, pancreatic, rectal, and breast cancers.
- Local control rates ranged from 40-100% based on cancer specifics and treatment intensity.
- Normal tissue tolerance is crucial for balancing tumor control and side effects.
Conclusions:
- IOeRT is an evidence-based treatment for multiple tumor types.
- Risk analysis for local recurrence aids in selecting patients for FLASH studies.
More Related Videos
08:31Sample Preparation and Experimental Design for In Situ Multi-Beam Transmission Electron Microscopy Irradiation Experiments
Published on: June 27, 2022
05:33Light-Induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction
Published on: July 26, 2022
Related Concept Videos
Overview of Electron Microscopy
Scanning Electron Microscopy
Fundamental Principles
Accelerated...
Transmission Electron Microscopy
X-ray Imaging
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...