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Related Experiment Video

Updated: Sep 1, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions.

Rajendra P Shukla¹, J G Bomer¹, Daniel Wijnperle¹

¹BIOS Lab-on-a-Chip Group, MESA+ Institute for Nanotechnology, Max Planck Center for Complex Fluid Dynamics, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Sensors (Basel, Switzerland)

|August 12, 2022

Summary

This summary is machine-generated.

Label-free field-effect transistor (FET) immunosensors show high sensitivity for proteomics and diagnostics. Fabricated FETs demonstrate stable pH sensing capabilities, paving the way for peptide-protein interaction detection.

Keywords:

diagnostics pH sensor peptide-protein interaction peptidomics planar junctionless FETs proteomics therapeutics

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Area of Science:

Biosensors and Nanotechnology
Surface Chemistry
Semiconductor Devices

Background:

Label-free immunosensors are crucial for proteomics and diagnostics, offering high multiplexing and fast response.
Field-effect transistor (FET) based sensors enhance sensitivity for detecting short peptides.

Purpose of the Study:

To fabricate and characterize planar junctionless FET sensors for pH sensing.
To evaluate the stability and surface properties of the fabricated FETs for biosensing applications.

Main Methods:

Fabrication of planar junctionless FET sensors with SiO2 gate oxide.
Characterization of sensor performance including voltage sensitivity and drain current drift.
Theoretical modeling and simulation of surface states.
Experimental verification of surface site immobilization (APTES, peptide, protein).

Main Results:

The FET sensor exhibited voltage sensitivity ranging from 37.6 to 41.8 mV/pH at various drain currents.
Stable sensor performance was observed with minimal drift over time (-0.45 to 0.01 pH/h).
Experimental surface site immobilization values aligned with theoretical calculations.

Conclusions:

The developed FET sensors demonstrate reliable pH sensing and stability.
The findings support the potential of these FETs for detecting peptide-protein interactions in future diagnostic and therapeutic applications.