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Diffuse epithelial ingrowth after perforating keratoplasty.

M Severin, B Kirchhof, C Hartmann

    Developments in Ophthalmology
    |January 1, 1987
    PubMed
    Summary
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    Diffuse epithelial ingrowth can occur after corneal graft surgery, particularly following perforating injuries. Early diagnosis and understanding its impact on intraocular pressure are crucial for patient outcomes.

    Area of Science:

    • Ophthalmology
    • Corneal Surgery
    • Histopathology

    Background:

    • Perforating keratoplasty is a surgical procedure to replace damaged corneal tissue.
    • Aphakia, the absence of the eye's natural lens, can complicate corneal grafts.
    • Diffuse epithelial ingrowth is a rare but serious complication following corneal transplantation.

    Observation:

    • Two cases of diffuse epithelial ingrowth after perforating keratoplasty in patients with aphakia are presented.
    • Epithelial invasion was potentially stimulated by spatula synecholysis in one case.
    • In the second case, ingrowth was observed 8 months post-keratoplasty, leading to ocular hypotension.

    Findings:

    • Histological examination was required for diagnosis in the first case after enucleation.

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  • Clinical diagnosis in the second case was based on characteristic slit-lamp findings.
  • The second patient developed band-shaped keratopathy secondary to decreased aqueous humor secretion and high outflow resistance.
  • Implications:

    • This condition highlights the importance of vigilant monitoring after corneal grafts, especially in aphakic eyes.
    • Understanding the mechanisms of epithelial ingrowth can guide preventative strategies.
    • The association with ocular hypotension and band-shaped keratopathy underscores the potential for significant visual impairment.