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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Air-stable aryl derivatives of pentafluoroorthotellurate
Daniel Wegener1, Kurt F Hoffmann1, Alberto Pérez-Bitrián1
1Fachbereich Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstraße 34/36, 14195 Berlin, Germany. s.riedel@fu-berlin.de.
Abstract:
We report on two different sets of air-stable derivatives of pentafluoroorthotellurate containing fluorinated and non-fluorinated aryl groups. The acid cis-PhTeF4OH was obtained in gram scale and further transformed to Ag[cis-PhTeF4O], which was used as a cis-PhTeF4O transfer reagent to obtain [PPh4][cis-PhTeF4O]. Furthermore, the synthesis of trans-(C6F5)2TeF3OH was achieved by a selective hydrolysis of trans-(C6F5)2TeF4 in the presence of KF and subsequent protonation by aHF. Quantum-chemical calculations show a higher acidity and robustness against fluoride abstraction for trans-(C6F5)2TeF3OH compared to cis-PhTeF4OH.
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