Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

284
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
284
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

251
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
251
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

175
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
175
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

143
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
143
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

152
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
152
Esophagus01:24

Esophagus

1.3K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab for Eosinophilic Esophagitis in Adolescents and Adults: Real-World Outcomes Across Different Dosing Regimens from the EoE CONNECT Registry.

The American journal of gastroenterology·2026
Same author

Early identification of emergency abdominal surgery candidates in the emergency department - a Delphi study.

Langenbeck's archives of surgery·2026
Same author

Active subperiosteal versus passive subdural 24-hour drainage following single burr hole evacuation of chronic subdural haematoma (the SUPERDURA trial): protocol for a multicentre, randomised non-inferiority trial.

BMJ open·2026
Same author

The short health scale for eosinophilic oesophagitis: validation and clinical applicability in 159 Danish patients.

Scandinavian journal of gastroenterology·2026
Same author

Subperiosteal Drain Insertion and Anchorage after Single Burr Hole Evacuation of Chronic Subdural Hematoma.

Journal of visualized experiments : JoVE·2026
Same author

Testing a structured End-of-Life care approach in Danish general practice settings.

BJGP open·2026

Related Experiment Video

Updated: Sep 1, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

895

[Eosinophilic oesophagitis in children].

Martin Hollænder Nielsen1, Kasper Bredal1, Jacob Holmen Terkelsen1

  • 1Klinisk Institut, Aalborg Universitet.

Ugeskrift for Laeger
|August 12, 2022
PubMed
Summary

Eosinophilic oesophagitis (EoE) is a growing concern, often underdiagnosed in children. Effective treatments exist, but confirming response requires histology due to symptom-histology discrepancies.

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

526

Related Experiment Videos

Last Updated: Sep 1, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

895
Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

7.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

526

Area of Science:

  • Gastroenterology
  • Immunology
  • Pediatrics

Background:

  • Eosinophilic oesophagitis (EoE) is a clinicopathological disorder marked by esophageal dysfunction and inflammation.
  • Rapidly increasing incidence of EoE globally, with significant underdiagnosis in pediatric populations, particularly in Denmark.
  • Untreated EoE leads to reduced quality of life and potential complications.

Purpose of the Study:

  • To review the current understanding of eosinophilic oesophagitis (EoE) epidemiology, clinical presentation, and management.
  • To highlight the diagnostic challenges and treatment efficacy in EoE.
  • To emphasize the need for histological confirmation in assessing treatment response.

Main Methods:

  • Literature review of studies on EoE incidence, diagnosis, and treatment.
  • Analysis of clinical data and histological findings in EoE patients.
  • Discussion of treatment outcomes with proton pump inhibitors, dietary changes, and topical corticosteroids.

Main Results:

  • EoE incidence is rising rapidly worldwide.
  • Pediatric EoE is significantly underdiagnosed, impacting quality of life and leading to complications.
  • Histological assessment is crucial for evaluating treatment response, as symptoms and histology conflict in 40% of cases.

Conclusions:

  • Eosinophilic oesophagitis (EoE) requires increased awareness and improved diagnostic strategies, especially in children.
  • Effective treatments are available, but careful monitoring including histological evaluation is essential.
  • Addressing underdiagnosis and optimizing treatment are key to improving patient outcomes in EoE.