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Updated: Aug 19, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Side effects of BCG vaccination with strain Copenhagen 1331
Abstract:
In the Federal Republic of Germany a BCG vaccine of strain Copenhagen 1331 is used. This vaccine was delivered with a content of 100,000 to 200,000 viable units per dose. Even in this small range one can see a relationship between spontaneously reported side effects, especially suppurated lymphadenitis in newborns. The lower the dosage the rarer the side effects. A diminution of viable units to a concentration of 100,000 to only 150,000 per dose shows a better compatibility though the conversion rate is still greater than 90%. Relevant side effects in schoolchildren or adults were not registered.
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