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The Evolving Landscape of ASCVD Risk Among Patients With HIV

Carlos Malvestutto1

  • 1Carlos Malvestutto, MD, MPH, Associate Professor of Medicine, Division of Infectious Diseases, The Ohio State University Wexler Medical Center, Columbus, Ohio.

The Journal of Family Practice
|August 12, 2022
PubMed

Insights

People with human immunodeficiency virus (HIV) face multiple atherosclerotic cardiovascular disease (ASCVD) risks. This summary covers risk factors, assessment, and safe statin use for managing dyslipidemia in HIV patients, avoiding drug-drug interactions.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Persons living with HIV (PWH) exhibit a higher burden of atherosclerotic cardiovascular disease (ASCVD) risk factors.
  • Understanding these factors is crucial for effective cardiovascular risk management in this population.

Purpose of the Study:

  • To summarize ASCVD risk factors in PWH.
  • To identify clinical assessment and risk stratification strategies.
  • To discuss dyslipidemia management challenges, including drug-drug interactions (DDIs) and safe statin implementation.

Main Methods:

  • Review of current literature on ASCVD risk factors in HIV.
  • Analysis of clinical guidelines for risk assessment and dyslipidemia management.
  • Focus on pharmacokinetic considerations for statin therapy in PWH.

Main Results:

  • Common ASCVD risk factors in PWH include traditional factors and HIV-specific elements.
  • Clinical assessment should integrate both traditional and HIV-related risks.
  • Dyslipidemia management requires careful selection of statins to avoid DDIs with antiretroviral therapy.

Conclusions:

  • Effective management of ASCVD in PWH necessitates a comprehensive approach.
  • Tailored risk stratification and vigilant dyslipidemia management, particularly statin selection, are key.
  • Minimizing DDIs is paramount for safe and effective treatment.
Abstract

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