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Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Antibiotic Selection

Antibiotic Selection

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

ProbResist: a database for drug-resistant probiotic bacteria.

Wanying Dou¹, Hemn Barzan Abdalla¹, Xu Chen¹

¹Department of Computer Science, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou, Zhejiang 325060, China.

Database : the Journal of Biological Databases and Curation

|August 13, 2022

Summary

A new online database, ProbResist, catalogs antibiotic-resistant probiotics to help combat drug resistance. This resource provides crucial data for medical practitioners and policymakers to track and manage resistant strains effectively.

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Last Updated: Sep 1, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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Published on: March 3, 2023

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay

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Published on: May 5, 2016

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Published on: July 9, 2012

Area of Science:

Microbiology
Genetics
Public Health

Background:

Drug resistance in probiotics poses a growing global health concern.
Probiotic foods may contain antibiotic-resistant determinants, increasing health risks.
Limited access to specific data on drug-resistant probiotics hinders control efforts.

Purpose of the Study:

To develop ProbResist, a manually curated online database of antibiotic-resistant probiotics.
To centralize and provide accessible information on drug resistance in probiotic bacteria.
To support efforts in combating the spread of antibiotic resistance.

Main Methods:

Manual curation of reported instances of antibiotic resistance in probiotics.
Development of a web server for searching resistance data by bacteria, antibiotic, or location.
Inclusion of downloadable tables with detailed resistance information and source identifiers.

Main Results:

ProbResist successfully catalogs experimentally verified antibiotic-resistant probiotics.
The database allows users to query and retrieve specific data on resistance profiles.
Results include probiotic species, antibiotic, resistance determinants, location, and source links.

Conclusions:

An exclusive database for drug-resistant probiotics is essential for managing public health risks.
ProbResist provides a centralized, accessible platform for critical resistance data.
The database will aid medical practitioners and policymakers in combating antibiotic resistance.